The road to phage therapy

Phage Therapy: Concept to Cure

The development and mass-production of antibiotics ranks as one of the twentieth century’s greatest scientific achievements. For more than 60 years, antibiotics have comprised Western medicine’s primary defense against bacterial disease. But although antibiotics have saved millions of lives, our chemical shield has become increasingly leaky. Just last year, the director-general of the World Hea...

Bacteriophage: Time to Re-Evaluate the Potential of Phage Therapy as a Promising Agent to Control Multidrug-Resistant Bacteria

Nowadays the most difficult problem in treatment of bacterial infections is the appearance of resistant bacteria to the antimicrobial agents so that the attention is being drawn to other potential targets. In view of the positive findings of phage therapy, many advantages have been mentioned which utilizes phage therapy over chemotherapy and it seems to be a promising agent to replace the antib...

Models of Virulent Phage Growth with Application to Phage Therapy

We modify existing models of bacteriophage growth on an exponentially growing bacterial population by including (1) density dependent phage attack rates and (2) loss to phage due to adsorption to both infected and uninfected bacteria. The effects of these modifications on key pharmacokinetic parameters associated with phage therapy are examined. More general phage growth models are explored whi...

Phage therapy

Bacteriophage therapy, the use of viruses that infect bacteria as antimicrobials, has been championed as a promising alternative to conventional antibiotics. Although in the laboratory bacterial resistance against phages arises rapidly, resistance so far has been an only minor problem for the effectiveness of phage therapy. Resistance to antibiotics, however, has become a major issue after deca...

The Long Road to Eradicate Rinderpest